A recent study suggests that people who stop using new GLP-1 drugs like Mounjaro or Wegovy can put back on lost weight at a significantly accelerated pace than those who stop traditional lifestyle plans.
Published data in a major medical journal demonstrates that while obese individuals often shed about a fifth of their total mass while on the medication, the weight returns at an average rate of nearly a kilo each month after stopping.
"Individuals buying these treatments must be cognizant of the potential of fast rebound weight gain when the therapy is stopped," warns expert Dr. Susan Jebb.
This pace of recovery suggests a return to original mass in about a year and a half.
Analyzing Treatments
The study, which reviewed 37 of trials involving over 9,000 of participants, compared the results of the injectable medications with conventional dieting.
Scientists point out that people who lose weight through dieting typically experience a slower creep back—perhaps 100 grams monthly—once they finish.
The Reason for the Rapid Rebound
Doctors propose the way of the drugs is key to understanding the amplified rebound.
GLP-1 drugs imitate a body's own chemical called GLP-1, which helps regulate hunger.
"Artificially providing the hormone concentrations several times higher than normal may cause the body to produce less of its endogenous hormone, and could reduce responsiveness to its effects," said Dr. Adam Collins, a nutrition researcher.
"Stopping of this hormone supplement results in hunger is unsuppressed, making overeating a significant risk."
A Lifelong Disease?
Medical guidelines suggest the jabs for individuals with weight-linked medical conditions, accompanied by prescribed lifestyle changes.
Many experts argue that, due to the likelihood of weight regain, the therapy should be considered ongoing.
This perspective is echoed by drug manufacturers, who note that the results "emphasize the persistent character of obesity," akin to managing diseases like diabetes.
Patient Testimonies
Individuals who have come off the medication report a sudden resurgence of cravings.
"It felt as if something flipping and you become extremely hungry," said one woman.
The struggle is exacerbated if individuals have not developed lasting dietary or behavioural modifications during therapy.
Widespread Interest
Survey data indicate that millions of adults in the UK have used these injections in the past year, with demand remaining high.
- Adoption is more common among females compared to males.
- The 40s and 50s age group shows the highest usage rates.
- A large proportion access the medications through private prescriptions rather than public health services.
Finally, experts caution that while these medications are potent agents for weight loss, they are not a magic solution and long-term success relies on integrated behavioural support.
